A mutational analysis of a complex gene in Drosophila melanogaster

2007 Impact statement
  • MacIntyre, Ross Joseph

abstract

We are investigating whether the process of genetic recombination induces or is associated with new mutations.

submitted by

issue being addressed

We need to know if areas of genomes that are subject to large amounts of crossing-over are places where new mutations might arise at high frequencies. This will affect the efficacy of selective breeding regimes.

response

We have set up an experimental system where we can select for the survival of recombinants and recover them in large numbers. We have also demonstrated and measured the rate of recombination within a repeated region of the gene we are using as a model system.

impact assessment

This is basic research. Demonstrating a regional basis for the quantitave induction of new mutations will guide future breeding programs, however.

academic priority area

topic description

Selection of new variants

has geographic focus

funding source description

  • Hatch
  • National Institutes of Health
  • National Needs
  • National Science Foundation
  • New York State Department of Agriculture and Markets

key personnel

Amber Carmon

mission focus

From CALS annual faculty reporting. Imported on August 5, 2008