My major interest is in a field of diabetes. For the last two and a half years we are working on the problem of the role of major antioxidant enzymes in glucose homeostasis. Glucose homeostasis, which is critical to an organism`s viability, is under tight insulin control. Malfunction of this system leads to metabolic disease - diabetes. The islets of Langerhans, the main structures involved in the regulation of insulin homeostasis, have been shown to be very vulnerable to oxidative stress. Therefore, oxidative stress might influence insulin homeostasis, and antioxidants, as well as antioxidant enzymes, might be implicated in the regulation of insulin metabolism. Therefore it is very important to evaluate the role of antioxidant enzymes in pancreatic insulin homeostasis.